PittsburghV1, France, Analysis, bibRecord, 000049

Cyclotriveratrylene-Based Glycoclusters as High Affinity Ligands of Bacterial Lectins from Pseudomonas aeruginosa and Burkholderia ambifaria

Identifieur interne : 000049 ( France/Analysis ); précédent : 000048; suivant : 000050

Cyclotriveratrylene-Based Glycoclusters as High Affinity Ligands of Bacterial Lectins from Pseudomonas aeruginosa and Burkholderia ambifaria

Auteurs : Nicolas Galanos [France] ; Yanan Chen [États-Unis] ; Zachary P. Michael [États-Unis] ; Emilie Gillon [France] ; Jean-Pierre Dutasta [France] ; Alexander Star [États-Unis] ; Anne Imberty [France] ; Alexandre Martinez [France] ; Sébastien Vidal [France]

Source :

RBID : Hal:hal-01470832

Abstract

The design of multivalent glycoconjugates has been largely studied using a variety of core scaffolds. Cyclotriveratrylenes (CTV) have been scarcely used in this context. The synthesis of the tri- and hexa-propargylated CTV cores allowed the prepn. of the corresponding glycoclusters with galactose or fucose residues through azide-alkyne "click" chem. Their interactions with bacterial lectins (LecA, LecB and BambL) was confirmed and studied by titrn. microcalorimetry. Adsorption onto carbon nanotubes was then attempted based on the hydrophobic CTV cores. Their incorporation into field effect transistor (FET) devices was accomplished but the data collected largely suggested a poor interaction of CTV-based glycoclusters with the carbon nanotubes leading to non-specific detection of the lectins.

Url:

https://hal.archives-ouvertes.fr/hal-01470832

DOI: 10.1002/slct.201601324

Affiliations:

Links toward previous steps (curation, corpus...)

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to stream Main, to step Exploration: 000055
to stream France, to step Extraction: 000049

Links to Exploration step

Hal:hal-01470832

Le document en format XML

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<author><name sortKey="Imberty, Anne" sort="Imberty, Anne" uniqKey="Imberty A" first="Anne" last="Imberty">Anne Imberty</name>
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<author><name sortKey="Vidal, Sebastien" sort="Vidal, Sebastien" uniqKey="Vidal S" first="Sébastien" last="Vidal">Sébastien Vidal</name>
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<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
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</placeName>
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<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
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</analytic>
<idno type="DOI">10.1002/slct.201601324</idno>
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<front><div type="abstract" xml:lang="en">The design of multivalent glycoconjugates has been largely studied using a variety of core scaffolds. Cyclotriveratrylenes (CTV) have been scarcely used in this context. The synthesis of the tri- and hexa-propargylated CTV cores allowed the prepn. of the corresponding glycoclusters with galactose or fucose residues through azide-alkyne "click" chem. Their interactions with bacterial lectins (LecA, LecB and BambL) was confirmed and studied by titrn. microcalorimetry. Adsorption onto carbon nanotubes was then attempted based on the hydrophobic CTV cores. Their incorporation into field effect transistor (FET) devices was accomplished but the data collected largely suggested a poor interaction of CTV-based glycoclusters with the carbon nanotubes leading to non-specific detection of the lectins.</div>
</front>
</TEI>
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<li>États-Unis</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
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</region>
<settlement><li>Grenoble</li>
<li>Lyon</li>
</settlement>
<orgName><li>Université Claude Bernard Lyon 1</li>
<li>Université Joseph Fourier</li>
<li>Université de Grenoble</li>
<li>Université de Lyon</li>
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<tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Galanos, Nicolas" sort="Galanos, Nicolas" uniqKey="Galanos N" first="Nicolas" last="Galanos">Nicolas Galanos</name>
</region>
<name sortKey="Dutasta, Jean Pierre" sort="Dutasta, Jean Pierre" uniqKey="Dutasta J" first="Jean-Pierre" last="Dutasta">Jean-Pierre Dutasta</name>
<name sortKey="Gillon, Emilie" sort="Gillon, Emilie" uniqKey="Gillon E" first="Emilie" last="Gillon">Emilie Gillon</name>
<name sortKey="Imberty, Anne" sort="Imberty, Anne" uniqKey="Imberty A" first="Anne" last="Imberty">Anne Imberty</name>
<name sortKey="Martinez, Alexandre" sort="Martinez, Alexandre" uniqKey="Martinez A" first="Alexandre" last="Martinez">Alexandre Martinez</name>
<name sortKey="Vidal, Sebastien" sort="Vidal, Sebastien" uniqKey="Vidal S" first="Sébastien" last="Vidal">Sébastien Vidal</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Chen, Yanan" sort="Chen, Yanan" uniqKey="Chen Y" first="Yanan" last="Chen">Yanan Chen</name>
</noRegion>
<name sortKey="Michael, Zachary P" sort="Michael, Zachary P" uniqKey="Michael Z" first="Zachary P." last="Michael">Zachary P. Michael</name>
<name sortKey="Star, Alexander" sort="Star, Alexander" uniqKey="Star A" first="Alexander" last="Star">Alexander Star</name>
</country>
</tree>
</affiliations>
</record>

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   |wiki=    Wicri/Amérique
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   |texte=   Cyclotriveratrylene-Based Glycoclusters as High Affinity Ligands of Bacterial Lectins from Pseudomonas aeruginosa and Burkholderia ambifaria
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Cyclotriveratrylene-Based Glycoclusters as High Affinity Ligands of Bacterial Lectins from Pseudomonas aeruginosa and Burkholderia ambifaria

Cyclotriveratrylene-Based Glycoclusters as High Affinity Ligands of Bacterial Lectins from Pseudomonas aeruginosa and Burkholderia ambifaria

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